The word calico, a fine variety of hand-woven cotton cloth that was exported from the port of Kozhikode, is thought to have been derived from Calicut. It is the historical capital of Kerala as the history dates back to 1498 AD when Vasco da Gama landed in Kappad, near Calicut.
During the Sangam period (3rd – 4th century BC), the land where Kozhikode now stands was an uninhabited region of the Chera Empire. This land, part of the larger Tamilakam partly fell within the Kudanad (Western land; west of Kongunad) to the south and partly within Puzhinad (marshy tract) to the north. The dominion of the Cheras extended as far as present-day Vatakara, beyond which lay the kingdom of Eli (Ezhi). The ports of the Chera empire played an important role in fostering trade relations between Kerala and the outside world. According to scholars, Tyndis or Tondi (present-day Kadalundi or Ponnani) to the south of Kozhikode was a flourishing seaport. During the 9th century, this region became a part of the Second Chera Empire. The Cheras (also known as Perumals) ruled the territory until 1102.

The rise of Calicut as a major trading centre and a port city does not seem to have happened before the 13th century. While the first reference to the Kingdom of Calicut and Saamoothiri is made by Ibn Battuta in his accounts (1342–1347), there is no reference to Calicut by Marco Polo, who visited Kerala towards the end of the 13th Century. He does, however, mention the kingdom of Eli. This provides a clue to a plausible date for the rise of Calicut as a major kingdom on the Kerala coast. Nevertheless, Prof. Krishna Ayyar has assigned 1034 CE as the year of the foundation of the city.[2]

According to the Keralolpathi (Genesis of Kerala), the last of the Chera kings, Cheraman Perumal, partitioned the kingdom among his feudatories and secretly left for Mecca with some Arab traders where he embraced Islam and lived the rest of his life in obscurity in Arabia. The date of this partition is a significant turning point in the history of Kerala. It is now clear that the Cheraman Perumals ruled in the 8th, 9th and 10th centuries and that the last Cheraman Perumal was Rama Varma Kulasekhara (1089–1102). Although there is no basis for the last Perumal's conversion to Islam and pilgrimage to Mecca, it is now accepted that following his mysterious disappearance the land was partitioned and that the governors of different Nadus (fiefdoms) gained independence, proclaiming it as their 'gift' from the last sovereign.[3]

There is some ambiguity regarding the exact course of events that led to the establishment of the zamorin's rule over Calicut. According to Prof. A. Sreedhara Menon (who entirely rejects the story of Cheraman Perumal's disappearance, his conversion to Islam and the subsequent gifts to his feudatories), immediately following the 'fall' of the Rama Kulasekhara, Calicut and its suburbs formed part of the Polanad Kingdom ruled by the Porlatiri.[4] The Eradis of Nediyirippu in Ernad (somewhere around present Kondotty) were land-locked and sought an outlet to the sea to initiate trade and commerce with distant lands.[5] To accomplish this, the Eradis marched with their nairs towards Panniyankara and besieged the Porlatiri in his headquarters, resulting in a 50-year war. The Eradis emerged victorious in their conquest of Polanad. After this, Menokkis were made as the ruler of Polanad and came to terms with the troops and people.[6] After this, the town of Calicut was founded close to the palace at Tali.[7] Then, the Eradis shifted their headquarters from Nediyirippu to Calicut. The Governor of Ernad built a fort at a place called Velapuram to safeguard his new interests. The fort most likely lent its name to Koyil Kotta the precursor to Calicut.

Zheng He's navigation chart from Hormuz to Calicut, 1430
However, M.G.S. Narayanan in his book, Calicut: The City of Truth states that the Governor of Eranad, Mana Vikrama (who became the Zamorin of Calicut later) was, in fact, a favourite of the last Ceraman Perumal, Rama Kulasekara as the former was at the forefront of the wars with the Chola-Pandya forces to the South and led the army to victory.[3] The King, therefore, granted him, as a mark of favour, a small tract of land on the sea-coast in addition to his hereditary possessions. This patch of wasteland is called Cullikkad in the Keralolpathi. To corroborate his assertion that Mana Vikrama was, in fact, a favourite of the last Perumal, Narayanan cites a stone inscription of the last ruler (1102) discovered at Kollam in South Kerala. It refers to Nalu taliyum ayiram arunurruvarum eranadu vazhkai Manavikiraman mutalayulla camantarum-'The four Councillors, The Thousand, The Six Hundred, along with Mana Vikrama, the Governor of Eranad and other Feudatories'.

However, the Eradis[8] being land-locked lacked direct access to the coastline as the territory of Polanad (Porakilanad) lay between Eranad and Calicut. Having been given the royal sword and the injunction Cattum konnum adakki kolka (conquer by courting and conferring death) by the last Ceraman (according to Keralolpathi), the Ernad Utayavar (Governor) waged war against the Porlatiri (Porakilar Adhikari) and attacked Panniyankara. M.G.S seems to indicate that the land sought by the Ernadis, lay in fact beyond and not within the kingdom of Polanad.

With the conquest of Polanad, the status of the Utayavar (Governor) increased and he became to be known as Swami Nambiyathiri Thirumulpad and the Kingdom of Calicut also came to known as Nediyiruppu Swarupam after the original house of the Eradis at Nediyiruppu. The king's title gradually evolved into Samoothirippadu or Saamoothiri or Saamoori over the years. The Europeans called him Zamorin. The foundation of the city of Calicut was therefore laid during the initial years of the 12th century.

The history of Kozhikode can roughly be divided into several periods marked by a few epoch-making events. These include the city's establishment, the arrival of the Portuguese, the arrival of the Dutch, the Mysorean Invasion, the rise of British Power, the beginning of the Indian Independence Movement and finally freedom from British rule in 1947